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Autoimmune encephalitis in a South Asian population

BMC Neurology May 28, 2021

Wickramasinghe N, Dasanayake D, Malavige N, et al. - This study was undertaken to examine the clinical characteristics in relation to their antibody status and outcomes of patients presenting with autoimmune encephalitis (AE) in Sri Lanka. Researchers prospectively recruited individuals who were admitted to government hospitals with AE over a period of 12 months. Commercial cell-based assays were used to investigate sera and cerebrospinal fluid for NMDAR, AMPAR1, AMPAR2, LGI1, CASPR2, GABARB1/B2 antibodies (Ab). A total of 142 patients from 21 of 25 districts in Sri Lanka (median age = 20.5 years; range 1–86 years; females = 61.3%) were included. Among South Asians, NMDAR-antibody encephalitis (NMDARE) is the commonest type of AE. The results illustrated that the clinical presentations of NMDARAb-positive and NMDARAb-negative AE patients do not significantly differ but EEG may be a beneficial marker of an autoimmune basis for psychiatric symptoms.

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