Ahmed F, Maclean RH, Nihtyanova SI, et al. - This study was attempted to evaluate the prevalence and burden of systemic sclerosis- (SSc) related gastrointestinal dysfunction (SSc-GI) and to assess relationships with demographic, clinical, and serological characteristics. In this cohort, 526 patients with SSc, with a typical distribution of disease-associated autoantibodies (ACA, ARA, ATA, PM-Scl, U1RNP, U3RNP) were included. Non-parametric and quantile regression analyses were used to evaluate questionnaire scores. In patients with SSc, there is a significant burden of SSc-GI disease; reflux and bloating symptoms are most prominent. The data demonstrate that SSc hallmark antibodies may prognosticate elevated risk of SSc-GI disease, in particular ACA and ARA, whilst PM-Scl may be protective.