Cohen CC, Perng W, Sauder KA, et al. - In the present study, the researchers sought to investigate correlations of dietary changes from childhood to adolescence with adolescent hepatic fat and whether the PNPLA3 rs738409 risk allele, a strong genetic risk factor for hepatic fat (HF), modifies associations. Data were from 358 candidates in the Exploring Perinatal Outcomes among CHildren (EPOCH) study, a longitudinal cohort in Colorado. The findings suggest that changes in nutrient intake between childhood and adolescence, specifically decreases in fiber and vegetable protein and increases in saturated fat intake, interact with the PNPLA3 variant to predict higher HF in adolescence and may be targets for decreasing HF in high-risk youth.