Rivera M, et al. – Via performing the PISMA-ep, a cross-sectional study that included a community-dwelling adult population, researchers examined how major depressive disorder (MDD) is associated with physical health-related variables in southern Spain. In all, they observed an association of MDD with chronic physical conditions (CPCs), obesity, and increased use of medication. Women, but not men, displayed a correlation of increases in BMI with MDD. In a multivariate model, MDD was identified to be associated with variables including female sex, obesity, general health status, cancer, peptic ulcer, tinnitus, and vertigo. The investigators recommended undertaking more holistic management of patients in the clinical practice in light of the high rates of comorbidity between MDD and CPCs. They noted a low rate of antidepressant use, indicating underdiagnosis.