Huang J, Li W, Wei S, et al. - In this retrospective observational study, in people with diabetic foot osteomyelitis (DFO), a lower estimated glomerular filtration rate (eGFR) is a risk factor for all-cause mortality and major cardiovascular adverse events (MACE). Furthermore, males with lower eGFR had a higher risk of all-cause mortality and MACE, whereas females did not.

• The sample consisted of 199 patients with DFO.

• Study participants were divided into three groups by eGFR: normal kidney function group (eGFR ≥ 90), mildly decreased kidney function group (eGFR 60– 89) and moderately to severely decreased kidney function group (eGFR < 60).

• All-cause mortality occurred in 51 (25.63%) of the 199 individuals during follow-up, 54 (28.72%) had MACE in 188 people, and 26 (48.15%) died.

• After fully adjusting for potential confounders, eGFR ≥ 90 mL/min/1.73 m ² had a lower incidence of all-cause mortality and MACE than eGFR < 90 mL/min/1.73 m ².

• eGFR ≥ 90 mL/min/1.73 m ² was also independently linked to a lower risk of all-cause mortality and MACE in males, but not in females, as compared with eGFR < 90 mL/min/1.73 m ².