Büttner M, et al. - In a large healthy working population, researchers explored the connection between blood pressure and other risk factors with retinal vessel diameters and its evolution over time at a younger age, as well as ascertained if current risk factors can be used as predictors for retinal vessel changes over time using a subsample of the population with time interval of three years. During a voluntary work health check in 2010 and 2013, retinal photographs and medical data were obtained. Utilizing a semi-automated software, the central retinal arterial equivalent (CRAE) and central retinal venular equivalent (CRVE) were evaluated. In total, 1,685 candidates had gradable photographs and full medical data with a mean age of 44.8 years (SD: 10.2) and 80.8% being male; full data were obtained in both 2010 and 2013 for 365 candidates allowing for longitudinal analysis. The longitudinal analysis demonstrated a mean reduction of −1.6 μm for CRAE and −2.0 for CRVE within the three-year time frame. The width of both arterial and venous retinal vessels reveals correlations not only with the blood pressure but also with cardiovascular risk biochemical markers. While these effects are partly known for elderly people, the findings of the study suggest that they also occur to working-age with seemingly unimpaired health in a young population.