Ebner F, et al. - In this post hoc sub-study of the Target Temperature Management trial, researchers tested the association of hyperoxemia and hypoxemia, time-weighted mean arterial partial pressures of oxygen (PaO₂), maximum PaO₂ difference, and gradually increasing PaO₂ levels (13.3–53.3 kPa) with poor neurological outcome in 939 patients after out-of-hospital cardiac arrest (OHCA) with return of spontaneous circulation (ROSC). They assessed the link between serial PaO₂ during 37 hours following ROSC, as well as neurological outcome at 6 months. Using Cerebral Performance Category (CPC), outcomes were dichotomized to good (CPC 1–2) and poor (CPC 3–5). According to the findings, one-third of the patients had hyperoxemia or hypoxemia exposure during the first 37 hours of hospitalization. Also, hyperoxemia or hypoxemia exposure was not significantly related to poor neurological outcome after 6 months or with the peak serum Tau (s-Tau) levels at either 48 or 72 hours after ROSC.