Knight-Greenfield A, Nario JJQ, Vora A, et al. - By performing this study with embolic strokes of undetermined source (ESUS) cases and cardioembolic strokes as controls, researchers examined the link between characteristics of nonstenosing atherosclerotic plaque on computed tomographic angiography and ESUS. They selected consecutive acute ischemic stroke patients, from 2011 to 2015, with unilateral anterior territory infarction on brain magnetic resonance imaging and a neck computed tomographic angiography. Cases with ≥ 50% internal carotid artery atherosclerotic stenosis ipsilateral to the stroke were removed from this study. Findings revealed greater total plaque thickness ipsilateral to the side of infarction than on the contralateral, stroke-free side, in ESUS cases. In cardioembolic strokes, no such side-to-side differences were visible. Overall, nonstenosing large-artery atherosclerotic plaques were suggested to be one underlying mechanism of ESUS.