Chen Y, Zelnick LR, Wang K, et al. - Researchers examined cross-sectional links of secretory clearances with iGFR [GFR (glomerular filtration rate) measured using ¹²⁵I-iothalamate clearance] and common metabolic complications of chronic kidney disease (CKD) in this analysis of 1,240 CKD patients from the multicenter Chronic Renal Insufficiency Cohort (CRIC) Study. Correlation and linear regression were applied for this purpose. Experts found that links between iGFR and secretory solute clearances ranged from ρ = +0.30 for hippurate to ρ = +0.58 for kynurenic acid. Higher serum levels of parathyroid hormone, triglycerides and uric acid were detected in relation to lower net clearances of most secretory solutes. Overall, findings showed modest correlations between tubular secretory clearances and measured GFR in adult patients with CKD. Lower net secretory clearances were found to be related to selected metabolic complications independent of GFR and albuminuria, indicating potential clinical as well as biological relevance.