van Dalen JW, Brayne C, Crane PK, et al. - According to findings, systolic blood pressure levels conveying the lowest dementia risk could vary between age groups and therefore require further trials of personalized blood pressure targets that consider individual life expectancy and health context.

• This is a cohort study of 7 studies with a total of 17,286 participants (mean (SD) baseline age was 74.5 (7.3) years), to determine if the link between systolic blood pressure and dementia risk is U-shaped and if age and comorbidity have a role in this relationship.

• A lower dementia risk in older individuals was observed in relation to higher systolic blood pressure, and a U-shaped association existed only in the oldest age groups.

• These links were not attributable to longer survival with lower systolic blood pressure.