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Association of systolic blood pressure with dementia risk

JAMA Feb 10, 2022

According to observations, systolic blood pressure levels conveying the lowest dementia risk could vary between age groups and therefore there is a need for further trials of personalized blood pressure targets that consider individual life expectancy and health context.

  • This is a cohort study of 7 studies with a total of 17,286 participants, wherein researchers investigated if the link between systolic blood pressure and dementia risk is U-shaped and if age and comorbidity have a role in this relationship.

  • In older individuals, a lower dementia risk was observed in relation to higher systolic blood pressure.

  • A U-shaped association was found only in the oldest age groups.

  • These links were not attributable to longer survival with lower systolic blood pressure.

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