Association of smoking, alcohol consumption, blood pressure, BMI, and glycemic risk factors with AMD
JAMA Dec 19, 2021
Kuan V, Warwick A, Hingorani A, et al. - Results from this study lend support to a potential causal association of alcohol intake with an elevated risk of geographic atrophy, smoking initiation and lifetime smoking with an elevated risk of advanced age-related macular degeneration (AMD), and smoking cessation with a reduced risk of advanced AMD.
In this Mendelian randomization study, it was inquired if smoking, alcohol intake, blood pressure, body mass index, and glycemic traits were related to elevated risk of advanced AMD.
A higher risk of advanced AMD (odds ratio [OR], 1.26) was observed in relation to a 1-SD increase in logodds of genetically predicted smoking initiation.
A lower risk of advanced AMD (OR, 0.66) was noted in relation to a 1-SD increase in logodds of genetically predicted smoking cessation (former vs current smoking).
Elevated risk of advanced AMD was evident in relation to genetically predicted increased lifetime smoking.
Genetically predicted alcohol intake was found to be linked with higher risk of geographic atrophy (OR per 1-SD increase of log-transformed alcoholic drinks per week, 2.70).
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