van der Linden V, et al. - In this multicenter cohort, 308 individuals were analyzed to study the clinical characteristics and imaging findings in candidates with congenital Zika syndrome (CZS) who developed hydrocephalus between 3 and 18 months of age who had at least 1 test positive for anti-Zika antibodies. They noticed that 58% of cases had symptoms and signs indicative of hydrocephalus like worsening seizures, vomiting, irritability, and/or sudden increase of head circumference percentile. About 78% of cases were noticed with cerebellar or brainstem hypoplasia on baseline imaging. They observed all subjects with increased ventricular volume, compatible with communicating hydrocephalus, and reduction of brain tissue that was visibly worse as compared to baseline imaging for the 23 cases with repeated scans.