Association of serum lipid parameters with the SCORAD index and onset of atopic dermatitis in children
Pediatric Allergy and Immunology Feb 04, 2021
Kim JH, Lee SW, Yon DK, et al. - Researchers explored the connection between dyslipidemia and atopic dermatitis in children by analysis of disease onset, risk factors, and disease severity. Subset I examined 7‐year‐old children in elementary school (n = 248), and Subset II was a retrospective long‐term follow‐up hospital‐based study (n = 52 725) performed from 1986 to 2016 which used propensity score matching. The Subset I study showed that children with atopic dermatitis (n = 69, 27.8%) had significantly higher TC and TG levels and that the SCORAD index was correlated significantly with high TC and TG levels and low HDL-C levels. The Subset II study (1,722 with high TC and 6,735 with normal TC after propensity score matching) showed the high TC group had a greater hazard ratio for the onset of atopic dermatitis during 5 years. The presence of atopic dermatitis and the SCORAD index are associated with an abnormal blood lipid profile in children. The risk of atopic dermatitis onset was significantly higher with high levels of TC.
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