Yu JJ, et al. - In this retrospective, longitudinal study, researchers evaluated the influence of the disorganization of retinal inner layers (DRIL) on visual acuity (VA) and its association with ischemic index (IsI) on ultra-widefield fluorescein angiography (UWFFA) in eyes with acute, treatment-naïve branch retinal vein occlusion (BRVO). For this investigation, they evaluated 30 eyes of 30 patients with a mean follow-up of 25.4 months ± 11.0 months. According to findings, DRIL served in an acute, treatment-naïve BRVO as an independent OCT biomarker for predicting worse VA over a period of two years. DRIL development was influenced by CME presence, intraretinal cyst area, and extent of ELM and EZ disruption, but not by baseline ISI severity. No association was found between baseline IsI on UWFFA and DRIL.