Wen W, et al. - In this functional network study, researchers explored the direct targets of pioglitazone and genes related to this drug by querying open platforms in order to build a biological function network, as well as evaluated the associations of pioglitazone with prostate cancer and pancreatic cancer. Results of this study suggested that pioglitazone is probably a causal risk factor for prostate cancer and pancreatic cancer. Therefore, caution should be taken while using this drug. In addition, they demonstrated the use of biological function network analysis to successfully assess drug interactions and drug safety profiles.