Coisne A, Montaigne D, Aghezzaf S, et al. - Findings indicate that there may not be an increased risk of mortality in asymptomatic patients with moderate aortic stenosis (AS) receiving standard symptomatic and echocardiographic follow-up.

• This is a cohort study of 2,703 patients with AS who were followed up by 117 cardiologists for a median of 2.1 years.

• Mild, moderate, and severe AS was present in 1,154 (42.7%), 1,122 (41.5%), and 427 (15.8%) patients, respectively.

• During a median of 2.1 years, 634 patients had aortic valve replacement (AVR) and 448 died before AVR.

• A slightly higher risk of cardiovascular death (hazard ratio, 1.47) was evident in patients with moderate AS vs those with mild AS, but this risk was much lower than that noted in patients with severe AS (hazard ratio, 3.66).

• Among asymptomatic patients, similar cardiovascular mortality was observed with moderate and mild AS (hazard ratio, 0.99).