Bernaudin F, et al. - In children with sickle cell anemia (SCA), researchers determined the link between matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) with transcranial Doppler (TCD) velocities as a surrogate for the occurrence of ischemic stroke. In this nonrandomized controlled intervention study that included 67 children with SCA, MSD-HSCT was significantly correlated with lower TCD velocities at 1 year vs standard care in children with SCA who require chronic transfusion due to persistently elevated TCD velocities.