Lourida I, Hannon E, Littlejohns TJ, et al. - Through a retrospective cohort study that included 196,383 people of European ancestry at least 60 years old with no dementia at baseline, experts examined whether a healthy lifestyle was related to a reduced risk of dementia, despite any genetic risk. Overall, 68.1%, 23.6% and 8.2% of individuals followed a favorable lifestyle, an intermediate lifestyle, and an unfavorable lifestyle, respectively. High polygenic risk scores, intermediate-risk scores, and low-risk scores was observed in 20%, 60% and 20% of the individuals. About 1.23% of the individuals with high genetic risk vs 0.63% of the individuals with low genetic risk, developed dementia. In comparison with 0.56% of individuals with low genetic risk and favorable lifestyle, 1.78% of the individuals with high genetic risk and unfavorable lifestyles developed dementia. No significant interaction between genetic risk and lifestyle factors was found. When contrasted with 1.78% with an unfavorable lifestyle, 1.13% of those with a favorable lifestyle developed dementia amongst individuals with high genetic risk. Both an unfavorable lifestyle and high genetic risk were significantly related to greater dementia risk among elderly adults without cognitive impairment or dementia. Moreover, among individuals with high genetic risk, a favorable lifestyle was correlated with lower dementia risk.