Atkins KM, Chaunzwa TL, Lamba N, et al. - In patients suffering from locally advanced non–small cell lung cancer (NSCLC), this retrospective cohort study was conducted to assess independent cardiac substructure radiotherapy factors for major adverse cardiac events (MACE) as well as all-cause mortality. This analysis involved 701 patients managed with thoracic radiotherapy for locally advanced NSCLC. The study sample had a median age of 65 years (interquartile range, 57-73 years). According to findings, differences may exist in optimal cardiac dose constraints on the basis of preexisting coronary heart disease (CHD). Although left anterior descending coronary artery V15 Gy greater than or equal to 10% seemed to be an independent estimator of the likelihood of MACE and all-cause mortality, especially in cases without CHD, an elevated risk of MACE in CHD cases was seemed to be conferred by left ventricle V15 Gy greater than or equal to 1%. Since there is a necessity for improved cardiac risk stratification as well as aggressive risk mitigation strategies, these constraints are worthy of further study.