Triches CB, et al. - Researchers assessed the link between endothelial dysfunction and cardiovascular risk factors, new-onset diabetes mellitus (DM), and cardiovascular outcomes, including death in patients with hypertension who were stratified into two groups according to the median value of basal asymmetric dimethylarginine (ADMA): those with high levels of plasma ADMA (>0.55 μmol/L) and low levels of plasma ADMA (≤0.55 μmol/L) who were prospectively evaluated over 5.8 years. Findings corroborated the link between high plasma ADMA levels and the presence of cardiovascular risk factors in patients with hypertension. Furthermore, in these subjects, a positive predictive value of high plasma ADMA levels for cardiovascular death was reported. An association between high ADMA levels and the development of type 2 DM was noted in a subgroup of patients with hypertension free from metabolic syndrome and DM at baseline.