Cook A, Hsia Y, Russell N, et al. - Researchers intended to determine if there is an association between empiric antibiotic regimen discordance and 30-day mortality in neonatal and pediatric bloodstream infection. Using REDCap through the Global Antibiotic Prescribing and Resistance in Neonates and Children network from February 2016 to February 2017, patient characteristics, antibiotic treatment, microbiology, and 30-day all-cause outcome from children < 18 years with blood-culture-confirmed bacterial bloodstream infections (BSI) have been collected anonymously. Twenty-five hospitals in 19 countries have registered 452 children with blood-culture-positive BSI receiving early empirical antibiotics. For patients undergoing a discordant early empiric antibiotic regimen, mortality rates in reported pediatric BSI are almost 3-fold higher. Further evaluation is needed of the impact of improved concordance of early empiric treatment on mortality, especially in critically ill patients.