Levy RV, Reidy KJ, Le TH, et al. - Findings demonstrate association of GSTM1 deletion with a more rapid progression of pediatric CKD post-adjustment in this large prospective cohort. No statistically significant links were observed with secondary outcomes (remission of proteinuria in children with glomerular disease and cardiovascular complications).

• In rapid progression of adult CKD, loss of function of the product of the GSTM1 gene has been implicated.

• This is a secondary analysis of a prospective observational cohort (n=674 children) assessing the link between deletions in GSTM1 and progression of CKD.

• At the time of analysis, 241 occurrences of the primary outcome (defined as a composite of 50% reduction in estimated glomerular filtration rate or start of kidney replacement therapy) were noted.

• CKD progression risk was 1.94 (1.27, 2.97) for exposed children, post-adjustment for baseline features.

• Similar effect size was observed with either one or two deletions (autosomal dominant inheritance).