Cavus E, Karakas M, Ojeda FM, et al. - Researchers sought for the circulating metabolites that are associated with incident coronary heart disease, and investigated their predictive value for the incidence of coronary heart disease in a large European cohort. In this population-based study, the BiomarCaRE case-cohort was used. The case-cohort comprised a weighted, random subcohort of an original cohort of more than 70,000 individuals. They analyzed a total of 141 metabolites. Findings revealed a significant association of 5 phosphatidylcholines (PCs)—acyl-alkyl-PC C40:6 (hazard ratio [HR], 1.13 [95% CI, 1.07-1.18]), diacyl-PC C40:6 (HR, 1.10 [95% CI, 1.04-1.15]), acyl-alkyl-PC C38:6 (HR, 1.11 [95% CI, 1.05-1.16]), diacyl-PC C38:6 (HR, 1.09 [95% CI, 1.04-1.14]) and diacyl-PC C38:5 (HR, 1.10 [95% CI, 1.05-1.16]))—with risk of incident coronary heart disease. These had comparable prognosticative values as individual classic risk factors.