Peng X, Wake M, Schultz MG, et al. - Given that the prediction of cardiovascular events, beyond conventional risk factors, is enabled by the reservoir pressure parameters [eg, reservoir pressure (RP) and excess pressure (XSP)] measured utilizing tonometry, but widespread use is prevented by the operator dependency of tonometry, and although a reasonable estimation of the intra-aortic RP and XSP from brachial volumetric waveforms can be achieved with an operator-independent cuff-based device, but it is unknown if these estimates are clinically relevant to preclinical phenotypes of cardiovascular risk, and this question was addressed in this study. Researchers included 1,691 mid-life adults from the CheckPoint study, to derive RP and XSP from brachial volumetric waveforms assessed via cuff oscillometry (SphygmoCor XCEL). As preclinical phenotypes of cardiovascular risk, they measured carotid intima--media thickness (carotid IMT, n = 1,447) as well as carotid--femoral pulse wave velocity (n = 1,632). Findings revealed a link of cuff-based XSP with carotid IMT, independently of conventional risk factors, including traditional BP, however, the observed link was weak, which calls for further inquiry to understand the clinical significance of reservoir pressure parameters.