Akwo EA, Robinson-Cohen C, Chung CP, et al. - This study was undertaken to investigate the hypothesis that the effect of apparent treatment-resistant hypertension (ATRH) on end-stage kidney disease (ESKD) is greater in Black patients than in White patients and investigated the effect of ATRH on ESKD independent of APOL1 genotype. Researchers conducted a retrospective cohort including a total of 139,685 hypertensive veterans (22% Black, 5% women) in the Million Veteran Program, ATRH was characterized as failure to achieve outpatient blood pressure < 140/90 mmHg with 3 antihypertensives including a thiazide or use of ≥ 4. It has been reported that individuals with ATRH experienced excess ESKD and cardiovascular disease risk. It was shown that this excess ATRH-related ESKD risk was magnified among Black individuals independently of APOL1 genotype. The findings suggested that targeted treatment of ATRH could curtail ESKD and cardiovascular disease incidence.