Orsi FA, et al. - A total of 127 venous thromboembolism (VTE, have a 1.6- to 3-fold increase in the risk of subsequent arterial cardiovascular events) subjects and 299 controls were randomly picked from the Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis study (1999–2004), in the Netherlands by the researchers in order to examine whether C-I, C-II, C-III and E apolipoproteins had prothrombotic characteristics and were correlated with the risk of VTE. Elevations in levels of apolipoproteins were linked to increases in levels of vitamin K-dependent factors, factor XI, antithrombin and clot lysis time, in controls. Moreover, rising apolipoproteins C-III and E levels were related to higher factor VIII and von Willebrand factor levels. Levels of C-reactive protein had no correlation with any apolipoprotein. The age- and sex-adjusted odds ratios were 1.21, 1.19, 1.24 and 1.06 for apolipoproteins E, C-III, CII and CI to the risk of venous thrombosis per SD increase, respectively. Following adjustments for statin use, estrogen use, BMI, alcohol use, and self-reported diabetes, these odds ratios did not attenuate. Hence, levels of apolipoproteins C-I, C-II, C-III and E were correlated with those of several coagulation factors. Nevertheless, whether these apolipoproteins were also correlated with a risen risk of VTE remained to be ascertained.