Association of anticholinergic drug use with risk for late age-related macular degeneration
JAMA Ophthalmology Jun 03, 2018
Aldebert G, et al. - Experts gauged the relationship between exposure to anticholinergic drug (ACD) and late age-related macular degeneration (AMD) (features of neovascular AMD or geographic atrophy of the retinal pigment epithelium in at least 1 eye). They conducted a multicenter case-control study in 4 French ophthalmologic centres comprising 200 cases with late AMD and 200 controls enrolled from July 2016 to June 2017. Findings suggested an increase in the risk of late AMD with at least 3 months’ use of ACDs. They noted an increased risk of AMD with ever exposure to ACDs, high Anticholinergic Burden Score, and longest cumulative exposure to ACD, suggesting a dose-effect association between them.
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