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Association between transplant glomerulopathy and graft outcomes following kidney transplantation: A meta-analysis

PLoS Neglected Tropical Diseases May 01, 2020

Kovács G, Devercelli G, Zelei T, et al. - Researchers analyzed evidence on the link between transplant glomerulopathy (TG) and graft loss or failure and time to these events, via a systematic literature review and meta-analysis done following the PRISMA statement. They used the Scopus, EBSCO, and Cochrane Library search engines to perform the literature review. The meta-analysis was performed with 21 eligible publications with 6,783 patients. In patients with TG vs those without, the combined hazard ratio of graft loss or failure from random-effects meta-analysis was 3.11. Findings revealed the link of TG with a threefold increment in the risk of graft loss or failure and a 15-year loss in graft survival, suggesting viability as a surrogate measure for both clinical practice as well as investigations designed to avert or reverse antibody-mediated rejection.

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