Jahan R, et al. - Via a retrospective cohort study of 6,756 subjects with acute ischemic stroke (AIS) from January 2015 to December 2016 in a US nationwide clinical registry, researchers described the correlation of speed of treatment with results among patients with AIS who underwent endovascular-reperfusion therapy. Adverse events were symptomatic intracranial hemorrhage (sICH) and in-hospital mortality/hospice discharge in 6.7% and in 19.6% of patients, respectively. At discharge, 36.9% and 23.0% were ambulated independently and had functional independence, respectively. Between 30 to 270 minutes vs 271 to 480 minutes, time-outcome relations were nonlinear with steeper slopes in the onset-to-puncture adjusted analysis. Faster onset to puncture in 15-minute increments in the 30- to 270-minute time frame correlated with a greater likelihood of obtaining independent ambulation at discharge, lower in-hospital mortality/hospice discharge, and lower risk of sICH. Including in the 30- to the 120-minute window, a higher likelihood of discharge to home and lower in-hospital mortality/hospice discharge was seen with faster door-to-puncture times for each 15-minute increment. Shorter time to endovascular-reperfusion therapy was significantly correlated with better outcomes in cases with AIS due to large vessel occlusion treated in routine clinical practice.