Wang A, et al. - In complicated, left-sided infective endocarditis (IE), researchers assessed clinical features connected to the timing of surgery and the connection between surgical timing and 6-month survival. Clinical features linked to the timing of surgery during the index hospitalization was assessed in 485 adult patients with definite, complicated, left-sided IE who had cardiac surgery during their index hospitalization in this prospective, multicenter, observational registry (The International Collaboration on Endocarditis-PLUS, registry from 2008 to 2012). In IE, there was a strong link between earlier surgery and acute heart failure and surgical urgency. Earlier surgery <7 days from admission was related to a trend toward higher 6-month overall mortality vs surgery later in the index hospitalization, after adjustment for operative risk and IE complications. A significant association was found between mortality and operative risk and complicated IE, including Staphylococcus aureus infection and the presence of an abscess.