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Association between the estimated glomerular filtration rate and brain atrophy in older adults

American Journal of Nephrology Feb 09, 2022

According to findings, a mild to moderately decreased estimated glomerular filtration rate (eGFR) was not linked with brain atrophy in Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants.

  • Using cross-sectional data from the ADNI, an NIH-funded multicenter longitudinal cohort study, researchers sought to further understand the link between eGFR and brain volumes.

  • This study included 1,596 participants who were 74 ± 7 years old with a mean eGFR of 69.4 ± 14.8 mL/min/1.73 m <sup>2</sup> ; 53% with mild cognitive impairment, and 19% had dementia.

  • In unadjusted analysis, a link was found between lower eGFR and smaller brain volumes.

  • No link existed between eGFR and brain volumes, post-adjustment for age, gender, and education.

  • These findings continued to be consistent following subgroup analysis by age stratification and baseline cognitive status.

  • Age was a confounding variable in the unadjusted link between the eGFR and brain volumes.

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