Kahn JM, et al. - Through a retrospective cohort study of 1,012,410 hospitalized adults with sepsis in New York State and in four control states (Florida, Maryland, Massachusetts, and New Jersey), researchers assessed the correlation between New York State sepsis regulations and the outcomes of subjects hospitalized with sepsis. Prior to the implementation of the sepsis regulations, 139,019 patients were admitted In New York State and 289,225 were admitted in the control states, while following the implementation of the sepsis regulations 186,767 were admitted in New York State and 397,399 were admitted in the control states. Mortality following the implementation of the regulations declined significantly in New York State in relation to the control states, after adjusting for patient and hospital traits and preregulation temporal trends and season. The regulations were correlated with no significant variations in intensive care unit admission rates, a significant relative drop in hospital length of stay, a significant relative drop in the Clostridium difficile infection rate, and a significant relative rise in central venous catheter use. Compared with sepsis mortality in control states that did not implement sepsis regulations, mandated protocolized sepsis care correlated with a higher reduction in sepsis mortality in New York State.