Abouk R, et al. - In this population-based study of data from the 2005-2016 National Vital Statistics System, researchers identified which types of naloxone access laws (NALs), if any, are associated with reduced opioid-involved fatal overdoses, and examined possible implications for non-fatal overdoses. NALs granting direct authority to pharmacists was linked to significant reductions in fatal overdoses in this evaluation of the dispensing of naloxone across the United States, but may also increase nonfatal overdoses in emergency department visits. Over time, the effect sizes for fatal overdoses increased relative to NAL adoption. While many states have passed some type of law affecting the availability of naloxone, only laws that allow pharmacists to directly dispense seem to be useful. Communities with improved access to naloxone should prepare for increased non-fatal overdoses and link these people to effective treatment.