Tanaka H, et al. - In order to determine whether scalp seizure-onset patterns could be specific to intracerebral seizure-onset patterns and to lesion type, the authors evaluated the association between scalp electroencephalography (EEG) and intracerebral EEG (iEEG) seizure-onset patterns in patients with focal lesional epilepsy. Findings revealed that some scalp seizure-onset patterns were highly associated with a specific intracerebral pattern, with specific pathologies, and with the depth of seizure-onset zone, in focal epilepsy patients with seizures generated in an MRI-visible lesion. These outcomes allowed the interpretation of scalp seizure-onset patterns to be significantly more informative.