Zhang J, Yan Y, Jiang P, et al. - The results illustrate that patients with rosacea have a high risk of cardiovascular diseases (CVD). There is a need for future studies to validate the relationship between rosacea and CVD.

• Using random-effects weighting, researchers conducted a pooled meta-analysis including 11 studies, which indicated increased odds for at least one risk factor of CVD, including diabetes, high blood pressure, or dyslipidemia.

• There was a correlation between rosacea and higher odds of insulin resistance or diabetes (odds ratio [OR], 1.18; 95% confidence interval [CI], 0.97-1.45), high systolic blood pressure (OR, 1.96; 95% CI, 1.35-2.84), dyslipidemia (OR, 1.50; 95% CI, 1.19-1.88), and CVD (OR, 6.65; 95% CI, 2.80-15.76).

• As per the findings, no publication bias was detected.

• Due to overlapping symptoms and lack of individual-level data, the effect of confounding factors was the limitation of this review.