Wang YH, et al. - Via involving data from Sweden from July 2006 to December 2016, researchers conducted this nationwide register-based cohort study to explore the correlation between proton pump inhibitor (PPI) use and risk of fracture in children. Children younger than 18 years of age who initiated PPI use were compared with those who did not initiate PPI use on propensity score and age. It included a total of 115,933 pairs of children. Increased risk of upper-limb fracture, lower-limb fracture and other fractures but not head fracture or spine fracture was correlated with the use of PPI. PPI use was linked to a small but significant increased risk of any fracture in this large pediatric cohort. The risk of fracture should be taken into account when assessing children's benefits and risks from PPI care.