Salari N, Darvishi N, Mansouri K, et al. - Researchers sought to systematically review and meta-analyze the relationship between PNPLA3 rs738409 polymorphism and non-alcoholic fatty liver. Articles were extracted from SID, MagIran, IranDoc, Scopus, Embase, Web of Science (WoS), PubMed, and ScienceDirect international databases using a systematic review and meta-analysis method. According to the findings of this meta-analysis, people with the CC genotype have a 52% lower risk of developing non-alcoholic fatty liver disease, while those with the CG genotype have a 19% higher risk. Those with the GG genotype were 105% more likely than others to develop non-alcoholic fatty liver. Furthermore, those in a population with CG + GG genotypes were 88% more likely to have non-alcoholic fatty liver disease.