Ge P, Ye X, Liu X, et al. - In patients with moyamoya disease, researchers explored the connection between p.R4810K variant and postoperative collateral formation (PCF). Among 254 Chinese moyamoya individuals, the p.R4810K variant was identified. For this investigation, they involved surgically treated 273 hemispheres with preoperative and postoperative digital subtraction angiography. To determine the influence factors for PCF, univariate and multivariate logistic regression analyses were performed. Among 254 individuals, 191 carried wild-type p.R4810K variant (GG) and 63 carried the heterozygous p.R4810K variant (GA). In GA patients, PCF was better than in GG patients on both lateral and anteroposterior views. Multivariate logistic regression analyses of p.R4810K variant and clinical variables demonstrated that GA was linked to a good PCF, on the other hand, the presence of hemorrhage was identified as a predictor of poor PCF. Overall, the authors concluded that the heterozygous p.R4810K variant was related to better PCF.