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Association between olfactory dysfunction and mortality in US adults

JAMA Otolaryngology-Head & Neck Surgery Jan 18, 2021

Choi JS, Jang SS, Kim J, et al. - In this nationally representative cohort study of 3,503 participants (1,831 women [52.3%]; mean [SD] age, 59.0 [12.0] years) 40 years or older, researchers intended to determine if there is an association between olfactory dysfunction and all-cause 5-year mortality in US adults. Olfaction was evaluated by self-report and objective test (8-odor Pocket Smell Test). Objectively measured olfactory dysfunction has been significantly linked to increased all-cause 5-year mortality among older adults independent of demographics, cardiovascular comorbidities, depression, and cognition. No association was found between self-reported olfactory dysfunction and mortality. Such results indicate that in older adults, objective olfactory dysfunction is associated with increased mortality. The correlation of olfactory dysfunction with mortality has consequences for physical and cognitive health, in addition to its impact on the quality of life.

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