Barcelos F, et al. - Researchers aimed to assess the distribution of B-lymphocyte subpopulations in primary Sjogren’s syndrome (pSS) and Sicca patients and to establish cut-off points that discriminate pSS from controls. They also gauged the relationship between memory B-cells and phenotypic features in pSS. As assessed by the European League Against Rheumatism (EULAR) Sjogren’s Syndrome Disease Activity Index (ESSDAI), in pSS, lower total memory B-cells count was related to longer disease duration and more active disease profile. Findings suggested that decreased numbers of memory B-cells clearly discriminated pSS from controls and could also have prognostic value. pSS patients had lower percentages and absolute numbers of memory B-cells vs controls.