Huang WD, et al. - A total of 185 Kawasaki disease (KD, a form of acute febrile systemic vasculitis that primarily affects children under the age of 5 years old) patient-caregiver dyads were included in a study by the researchers to review the perinatal factors and clinical outcome of KD, including coronary artery lesion (CAL) formation and intravenous immunoglobulin (IVIG) treatment response. KD subjects with CAL formation had a higher maternal age in comparison to non-CAL cases. The maternal age ≥32 years group had a greater rate of having KD subjects with CAL. The maternal age ≥35 years group had a greater rate of having KD subjects with IVIG resistance. In respect to the subject’s age at disease onset, gestational age, birth bodyweight, delivery methods, breastfeeding, caregiver type, caregivers’ education level, the total number of offspring, or family income, no important variation in either CAL formation or IVIG resistance in KD was found. Hence, in KD, via the first study that first to reported that maternal age had a significant correlation with CAL formation and IVIG resistance. Thus, it was presumed that the maternal age of less than 32 years would profit the KD offspring.