Lechien JR, Hans S, Simon F, et al. - Studies were selected via a search of PubMed, Scopus, and Cochrane Library to explore the connection between laryngopharyngeal reflux (LPR) and recurrent (ROM) or chronic otitis media with effusion (COME). Using PRISMA criteria, inclusion, exclusion, diagnostic criteria, and clinical outcome evaluation of included studies were analyzed. Inclusion criteria were met by 26 clinical and three experimental articles, accounting for 1,624 children and 144 adults with COME or ROM. The link between LPR and OM is still unknown. Future clinical and experimental studies are required to investigate the relationship between LPR and OM in both children and adults using extensive gastric content analysis in middle ear suppurations and impedance-pH monitoring taking acid, weakly acid, and alkaline reflux events into account.