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Association between high school personality phenotype and dementia 54 years later in results from a national US sample

JAMA Oct 24, 2019

Chapman BP, Huang A, Peters K, et al. - Researchers examined whether maladaptive personality traits during adolescence confers dementia risk in later life, and investigated if relationships could be accounted for by health factors in adolescence or differed across socioeconomic status (SES). They conducted a cohort study involving 82,232 participants in the United States. Members of Project Talent, a national sample of high school students in 1960, were included as participants. The investigators identified individuals who received a dementia-associated International Classification of Diseases, Ninth Revision (ICD-9) code during any year between 2011 and 2013. The analysis revealed personality traits in adolescence as a factor correlated with incident dementia almost 5 decades later in a national US cohort. Dementia less frequently developed among calm and mature adolescents, and with higher socioeconomic status, this risk reduction was significantly more pronounced.

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