Szabo SM, et al. - Among 154,432 adults with overactive bladder (OAB) and 86,966 adults without OAB, researchers analyzed the connection between cumulative anticholinergic burden and falls and fractures. The increased risk of falls and fractures was 23% among those with low burden, 30% among those with medium burden and 38% among those with the high burden vs those without anticholinergic burden. Compared to those without OAB, falls and fracture rates among those with OAB were about 40% higher. These data suggest that significant risk factors for falls and fractures are seen with both urinary symptoms and anticholinergic burden. Overall, the authors concluded that higher levels of anticholinergic burden were linked to higher rates of falls and fractures, emphasizing the importance of anticholinergic burden in the treatment of OAB patients.