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Association between birth weight and neurodevelopment at age 1–6 months: Results from the Wuhan Healthy Baby Cohort

BMJ Open Jan 10, 2020

Zhang M, Gazimbi MM, Chen Z, et al. - Investigators conducted a prospective cohort study involving 4,026 children from the Wuhan Healthy Baby Cohort (WHBC) study who were born at the Women and Children’s Hospital of Wuhan, China and had complete healthcare records within 6 months after birth to investigate the impact of birth weight on neurodevelopment of infants at age 1–6 months utilizing data from the WHBC study. Of the 4,026 infants, 166 were of low birth weight (LBW) and 23 had macrosomia. Overall, LBW had no significant impact on “neurodevelopmental delay” in language and social behavior, and macrosomia had no significant impact on clinical diagnosis of “neurodevelopmental delay” in all domains. Both LBW and macrosomia were correlated with infants’ development quotient, and LBW elevated the risk of a diagnosis of “neurodevelopmental delay” in gross motor, fine motor, and adaptability among infants 1–6 months of age.

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