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Association between anaesthetic dose and technique and oncological outcomes following surgical resection of non-small cell lung cancer

Journal of Cardiothoracic and Vascular Anesthesia Mar 31, 2021

de La Motte Watson S, Puxty K, Moran D, et al. - Researchers undertook this retrospective cohort analysis to examine the link between anesthetic technique and dose and oncological result in NSCLC surgery. This study included 746 patients receiving elective lung resection for NSCLC between January 2010 and December 2014, and these were split into those undergoing total intravenous anesthesia only (n=342) and those exposed to volatile anesthetics (n=404). For either cancer specific or overall survival, there was no significant difference. Employing Cox Proportional Hazards Modelling, experts assessed factors impacting survival, and it was found in univariate and multivariate Cox analysis that anesthetic type was not a significant predictor for cancer specific or overall survival. Overall, findings revealed the absence of a significant link between anesthetic technique and NSCLC survival. Definitive inquiry in a prospective, randomized trial is warranted to determine if there is a causal link between anesthetic technique during NSCLC surgery and oncological result.

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