Hologlu D, Gunes S, Asci R, et al. - Findings demonstrate a detrimental impact of chromatin condensation on male fertility potential, in view of its negative link with semen parameters, especially sperm morphology.

• This study involved 32 infertile and 10 proven fertile men, and semen samples from infertile men with oligoasthenoteratozoospermia were analyzed.

• Significantly lower chromatin condensation sperm was detected in infertile men vs the fertile men (p < 0.0001).

• Factors significantly negatively correlated with chromatin condensation included age, sperm concentration, morphology and motility.

• In terms of 8-OHdG concentration, there were no significant correlations among the chromatin condensation, SDF and sperm DNA damage.

• Seemingly, chromatin condensation in terms of chromatin compaction affords a parameter that should be considered apparently, more in cases receiving ICSI because this patient group had a significantly higher frequency of chromatin condensation defects.