Tetens MM, Haahr R, Dessau RB, et al. - This study was attempted to assess the risk of psychiatric disease, the percentage of psychiatric hospital inpatient and outpatient contacts, and the receipt of prescribed psychiatric medications among patients with Lyme neuroborreliosis compared with individuals in a matched comparison cohort. Between January 1, 1995, and December 31, 2015, researchers conducted a nationwide population-based matched cohort study including all residents of Denmark who received a positive result on an intrathecal antibody index test for Borrelia burgdorferi (patient cohort). For this analysis, 2,897 patients with Lyme neuroborreliosis (1,646 men [56.8%]) and 28,970 individuals in the matched comparison cohort (16,460 men [56.8%]) were included with a median age was 45.7 years (interquartile range [IQR], 11.5-62.0 years) for both groups. The data indicated that patients with Lyme neuroborreliosis did not have an increased risk of developing psychiatric diseases that required hospital care or treatment with prescription medication. In this population-based matched cohort study, the elevated receipt of psychiatric medication among patients with Lyme neuroborreliosis within the first year after diagnosis, but not thereafter, implies that most symptoms correlated with the diagnosis subside within a short period.