Gist KM, et al. - By performing this secondary analysis of the Acute Kidney Injury in Children Expected by Renal Angina and Urinary Biomarkers prospective observational study, researchers assessed the independent as well as synergistic links of fluid overload and acute kidney injury with outcome in critically ill pediatric patients. The inquiry was performed at a single-center quaternary level PICU. Participants included 149 children (3 months to 25 years old) with predicted PICU length of stay more than 48 hours and an indwelling urinary catheter. According to the findings, the influences of significant fluid accumulation may be delineable from the impacts of acute kidney injury. A significant worsening of the outcome was noted in relation to concurrent fluid overload and acute kidney injury. The possible consequences of correction of acute kidney injury evaluation for net fluid balance include improved diagnosis and the unveiling of acute kidney injury related to deleterious downstream sequelae.